Ketosis in Extreme Environments: Mitigating Central Nervous System Oxygen Toxicity
A single dose of this ketone ester (BD-AcAc2) rapidly induces deep ketosis, similar to prolonged fasting or a strict ketogenic diet, elevating both AcAc and BHB above 3.0 mmol/L. Remarkably, this level of therapeutic ketosis in rodent model studies was achieved when feeding a standard high-carbohydrate rodent chow.
To study the effects of the ketone ester on CNS-OT, rats were administered the ketone ester and then placed in the hyperbaric chamber, pressurized to 5 ATA, which is equivalent to 132 feet of sea water.
Our results showed the ketone ester BD-AcAc2 delayed time to seizure by 574%:
- Without ketone ester (control): seizure within 5-10 minutes
- With ketone ester (BD-AcAc2): seizure after 50+ minutes
Note: Results like this have only been achieved with anti-epileptic drugs at doses that would leave the individual generally incapacitated from the high level of sedation.