KETONES
RESEARCH
PORTAL
The scientific research behind ketones is very clear... and exponentially growing!
We live in a world where all of the information you could possibly want to know is available in the palm of your hand. However, even though this information is available if you can’t find it or don’t understand it’s meaning, what purpose is it serving? Searching databases for research papers on the exact condition you are looking for can be time-consuming. That’s where we come in! We are here to help make the research more widely available to as many people as possible. Below, you will find credible information from countless studies, journals, and publications that contain valuable insight into exogenous ketones. Easily navigate through all of the content that you want to find either using the search bar atop this page or choosing a category of interest.
This isn’t a static resource bank either! Make sure you are checking back with us frequently because we will be updating our database when new research is published! Stay up-to-date and informed on the latest ketone research with this Exogenous Ketone Resource!
Alzheimer’s Disease (AD)
- 2000: d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
- 2004: Effects of beta-hydroxybutyrate on cognition in memory-impaired adults.
- 2008: Ketone bodies as a therapeutic for Alzheimer’s disease
- 2016: Ketones block amyloid entry and improve cognition in an Alzheimer’s model
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2019: Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)
- 2020: A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer’s Disease
- 2020:β-hydroxybutyrate Impedes the Progression of Alzheimer’s Disease and Atherosclerosis in ApoE- Deficient Mice
Amyotrophic Lateral Sclerosis (ALS) / Lou Gehrig’s Disease
- 2013: High-Fat and Ketogenic Diets in Amyotrophic Lateral Sclerosis – Sabrina Paganoni, Anne-Marie Wills, 2013
- 2015: Nutritional/Metabolic Therapies in Animal Models of Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, and Seizures
- 2017: Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments
Angelman Syndrome
Anxiety
- 2017:Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2018:Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Attention-Deficit Disorder (ADHD)
- 2017: The Current Status of the Ketogenic Diet in Psychiatry
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
Autism / Autism Spectrum Disorder (ASD)
- 2016: Metabolism-Based Treatments for Autism Spectrum Disorder and Co-Morbidities
- 2017: Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches
- 2017: The Current Status of the Ketogenic Diet in Psychiatry
- 2017: Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?
- 2018: ketogenic diet as possible therapy of autism spectrum disorder — review and implication
Bipolar Disorder
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
- 2019: Ketosis and bipolar disorder: controlled analytic study of online reports | BJPsych Open
Cancer
- 2014: Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer
- 2015: Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice
- 2016: Metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet as a cancer therapy?
- 2019: Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma
- 2019: HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma
CNS Toxicity
- 2013: Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats
Crohn’s Disease
Depression
Diabetes (Type 2 Diabetes Mellitus)
- 2016: Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats
- 2016: Diabetic ketosis during hyperglycemic crisis is associated with decreased all-cause mortality in patients with type 2 diabetes mellitus
- 2018: Exogenous ketones lower blood glucose level
- 2018: The glucose‐lowering effects of exogenous ketones: is there therapeutic potential?
- 2019: Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models
- 2020: Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes in: European Journal of Endocrinology Volume 182 Issue 2 (2020)
Dravet Syndrome
Epilepsy/ Seizures
- 1999: Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet
- 2000: The Ketogenic Diet: Seizure Control Correlates Better With Serum β-Hydroxybutyrate Than With Urine Ketones
- 2004: More fat and fewer seizures: dietary therapies for epilepsy
- 2012: Ketone bodies in epilepsy
- 2015: Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
- 2017: Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats
- 2019:Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives
- 2019: Exogenous Ketone Supplementation Decreased the Lipopolysaccharide-Induced Increase in Absence Epileptic Activity in Wistar Albino Glaxo Rijswijk Rats
Exercise Performance
Flu (influenza)
GERD/Acid Reflux/Esophageal Ulcers
- 2006: A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms.
- 2016: Dietary carbohydrate intake, insulin resistance and gastro‐oesophageal reflux disease: a pilot study in European‐ and African‐American obese women
GLUT1 Deficiency Syndrome (GLUT1DS)
- 2017: Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency
- 2018: Exogenous ketones lower blood glucose level
- 2019: Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models
Glycogen Stoarge Disease (GSD)
- 2005: Treatment of glycogenosis type V with ketogenic diet
- 2011: Successful Treatment of Severe Cardiomyopathy in Glycogen Storage Disease Type III With D,L-3-Hydroxybutyrate, Ketogenic and High-Protein Diet
- 2015: Ketogenic diets in patients with inherited metabolic disorders
Hyperlipidemia
Inflammatory Diseases
- 2015: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- 2017: The promising potential role of ketones in inflammatory dermatologic disease: a new frontier in treatment research
- 2017: The effects of exogenous ketones on biomarkers of Crohn’s Disease
- 2017: Characterizing the metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet
- 2018: Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health
Lyphedema
MAAD (multiple acyl-CoA dehydrogenase deficiency)
- 2014: Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency–related leukodystrophy2019: Long-term ketone body therapy of severe multiple acyl-CoA dehydrogenase deficiency: A case report
Migraines
- 2014: Migraine improvement during short lasting ketogenesis: a proof‐of‐concept study
- 2019: Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial
- 2019: Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention
Multiple Sclerosis (MS)
- 2012: Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis2020: Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study
Obesity
Pain/ Chronic Pain
Parkinson’s Disease (PD)
- 1999: d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2019: Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)
Polycycstic Kidney Disease (PKD)
Polycystic Ovary Syndrome (PCOS)
- 2005: The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study
- 2020: Effects of a ketogenic diet in overweight women with polycystic ovary syndrome
Post-Traumatic Stress Disorder (PTSD)
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats2019: Nuclear magnetic resonance spectroscopy based urinary metabolic profiling in post traumatic stress disorder rats2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current
Rett Syndrome
Sarcopenia
Schizophrenia
- 2018: Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
- 2018: The effects of the ketogenic diet on psychiatric symptomatology, weight and metabolic dysfunction in schizophrenia patients
- 2019: Ketogenic diet prevents impaired prepulse inhibition of startle in an acute NMDA receptor hypofunction model of schizophrenia
- 2019: Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature
- 2019: Ketogenic diet for schizophrenia: clinical implication : Current Opinion in Psychiatry
Stroke
Traumatic Brain Injury (TBI)
- 2004: Increased cerebral uptake and oxidation of exogenous βHB improves ATP following traumatic brain injury in adult rats
- 2005: Age‐dependent reduction of cortical contusion volume by ketones after traumatic brain injury
- 2007: Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury – Mayumi L Prins, 2008
- 2008: Fasting is neuroprotective following traumatic brain injury
- 2011: Clinical review: Ketones and brain injury | Critical Care | Full Text
- 2018: Modulation of cerebral ketone metabolism following traumatic brain injury in humans